Endocrine Abstracts

IntroductionModern diabetology is focused on preventing late complications of diabetes and to find research tools to detect discrete changes, with the possibility of early entry with treatment. Type 1 diabetes (DM1) causes oxidative stress, affects the cardiovascular system and increases vascular stiffness. The non-invasive measurement of central blood pressure (CBP) together with augumentation and aplification indicators, more accurately reflects the co...

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is the most common disorder, in which lack of the enzyme causes deficiency aldosterone and cortisol. The result of this deficiency is an increased level of ACTH. The classic form appears in early childhood and may be associated with the development of abnormal genitalia. Clinically older patients present the GnRH-independent precocious puberty with rapid growth and advanced bone age. We present the case of 9-year-...

Introduction: Association between autoimmune thyroid disease (AITD) and other autoimmune disorders is common and known as autoimmune polyglandular syndrome (APS). It may involve hypoparathyoridism with Addison disease (AD) and mucocutaneous candidiasis – APS type I, AD with Diabetes mellitus type 1 (DM1) or AITD- APS type II, AITD associated with other autoimmune diseases (excluding AD): DM1- type IIIa, pernicious anemia- IIIb, or alopecia and/or vitiligo and/or other aut...

Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves’ disease and in children with Hashimoto’s thyroiditis.The study group formed 78 patients suffering from Graves’ disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and ...

The risk of malignancy in thyroid nodules correlates with the presence of ultrasound features. In adults, ultrasound risk-classification systems have been proposed to indicate the need for further invasive diagnosis. Furthermore, elastography has been shown to support differential diagnosis of thyroid nodules. The purpose of our study was to assess the application of the American Thyroid Association (ATA) and British Thyroid Association (BTA) ultrasound risk-classification sys...

Graves’s disease is the most common type of autoimmune hyperthyroidism. Numerous studies indicate different factors contributing to the onset of the disease. Despite years of research, the exact pathomechanism of Graves’ disease still remains unresolved, especially in the context of immune response. B cells can play a dual role in autoimmune reactions, on the one hand, as a source of autoantibody mainly targeted in the thyroid hormone receptor (TSHR) and, on the othe...

Introduction: Bloom syndrome (BS) is a rare autosomal recessive disorder caused by mutations in the BLM gene. Classic dysmorphic features include a long, narrow face, micrognathism and prominent nose and ears. Other features of the disease include pre- and post-natal growth failure, skin rash following sun exposure, hyper-pigmented areas or cafe-au-lait lesions, high-pitched voice and immunodeficiency. The most serious complication of BS is the significant increase in...

Up till now, altered balance of T helper 1 (Th1) and Th2 immune cells has been postulated to play an important role in the pathogenesis of autoimmune thyroid diseases (AITD). However, recent studies on thyroid diseases suggest a new role for Th17 (T helper 17) cells which have the ability to secrete cytokines: IL17, IL17F, IL21, and IL23. The aim of the study was to estimate the proporcions of circulating CD4+CD161+CD196+ and CD4+IL17+ Th17 cells and serum concentrations of IL...

TIAR and TIA-1 are two closely related RNA-binding proteins, which possess three RNA recognition motifs (RMMs). These proteins are involved in several mechanisms of RNA metabolism, including regulation of mRNA translation. In cellular apoptosis continuously TIAR shuttled between the cytoplasm and nucleus.The aim of this study was to estimate expression of closely related mRNA binding proteins TIAR and TIA-1 in thyroid tissues from young patients with Gra...

Graves’ disease (GD) is hyperthyroidism associated with organ-specific autoimmune 14 inflammation. GD occurs more frequently in adults than in children, however, pediatric patients are 15 a therapeutic challenge due to cycles of remissions and relapses requiring constant monitoring at 16 every stage of treatment administered. Dendritic cells (DCs) are considered a link between innate 17 and adaptive immunity. DCs as antigen-presenting cells (APCs) are involved in antigen ...